Born in Rome, he began studying the  at the National Conservatory “Santa Cecilia” under Salvatore de Girolamo, where he received his diploma with highest honours in 1990.

He pursued his graduate studies at the “International Academy Mozarteum” in Salzburg with Maurice Gendron and in Italy with Nicolae Sarpe and Alfredo Stengel.

He received his graduate diploma in Chamber Music with Felix Ayo at the Accademia di Santa Cecilia and an Honorary Chamber Music diploma at the Accademia Chigiana in Siena with Riccardo Brengola.

As soloist and chambriste he has been engaged for performance by the Italian Radio (RAI) in Rome, by the Accademia Filarmonica Romana, the Baroque Academy of Rome, the Accademia Chigiana in Siena, the Accademia Filarmonica in Messina,  the Fondo per l’Ambiente Italiano (FAI), and the Teatro Argentina in Rome.

In addition he has been invited to play in numerous International festivals and musical congresses: Appuntamenti Musicali Estivi of the Accademia Chigiana, the Massimo Aphiteatrofffestival in Levanto, Nuits Musicales in Cannes, Italian Cultural Festival in Dortmund, Cello Festival in Dijon, Festival of Saint Sernin du Plain. In 1997, he was on the program of the Chamber Music season of the Accademia Nazionale di Santa Cecilia accompanying the famed soprano Renata Scotto with his quartet from the Giovani Musici Italiani. From 1996 to 2001 he was president and first cello solo of the Giovani Musici Italiani ensemble with whom he made a series of discs for Dynamics Records and a collection of Baroque works edited by the reviewAvvenire, which was singled out for high praise by the press.

In 2000 Mr. Romano received the prize of the City of Rome from the Presidente del Consiglio “…for highly qualified and diligent artistic and professional activity…”

He has held master classes in France (National Regional Conservatory of Dijon) and in Syria (Superior Conservatory of Damascus) and he regularly holds summer courses in Italy in collaboration with the Luxembourg Association “Il Suono in Movimento".

He has held the chair of first cello in the following institutions: Teatro del Maggio Musicale in  Florence, Teatro la Fenice in Venice, Teatro Lirico of Cagliari, Opera of Dijon, Philharmonic Orchestra of Luxembourg, Teatro Giuseppe Verdi of Trieste.

He is frequently invited by the conductor Daniel Oren to play first cello with the orchestra of the Teatro Lirico Giuseppe Verdi of Salerno.

Since 2006 he has been named first cello of the Teatro Carlo Felice of Genoa. He plays in duos and trios with his wife, first clarinettist of the Teatro Carlo Felice, Valeria Serangeli and  the pianist Corrado de Bernart.

Federico Romano plays a cello made in Cremona by Enrico Ceruti  in 1852. He also plays a cello made in Dijon by Gunter Sifiert in 2011.